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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
A, B

  • Other antidepressants (Ex. linezolid, tricyclic antidepressants)
  • EICHOTHERM (Ex. linezolid, linezolid combinations, linezolid derivatives)

C.

Here are the key drug-food Interactions:

  1. Grapefruit and Grape Juice: Grapefruit can increase the levels of tadalafil by inhibiting the metabolism of tadalafil. This increases the blood pressure by delaying the absorption of the drug into the bloodstream.
  2. : Though this interaction less severe, exposure to excessive alcohol can still cause QT prolongation (a potentially life-threatening prolongation of the aqueous flow). Avoid alcohol in individuals with moderate or severe heart disease.

What is Cialis?

Cialis is a medication primarily used to treat erectile dysfunction. It contains the active ingredient tadalafil, which belongs to a class of medications called phosphodiesterase type 5 inhibitors. It is generally considered safe for most men, but it can sometimes cause side effects such as headache, flushing, and dizziness. It is typically taken by mouth, typically about 30 minutes before sexual activity. Cialis should not be taken more than once a day.

Erectile dysfunction medications can have side effects, including:

  • Headaches
  • Flushing
  • Indigestion
  • Nasal congestion
  • Dizziness
  • Visual disturbances
  • Drowsiness
  • Dry mouth

If your doctor decides to stop using Cialis, it is important to follow their guidance and monitor your progress closely. This medication can cause side effects such as:

  • Nausea
  • Vomiting
  • Back pain

If you experience any of these side effects, it is important to contact your doctor immediately. If you experience any of these symptoms, it is important to contact your doctor immediately.

How does Cialis work?

Cialis contains the active ingredient tadalafil, which belongs to a class of medications called phosphodiesterase type 5 inhibitors. It works by relaxing the blood vessels in the penis, allowing for increased blood flow during sexual arousal. This increased blood flow helps achieve and maintain an erection.

Cialis does not cure erectile dysfunction, but it can help manage this condition. If you are experiencing erectile dysfunction or other sexual problems, it is important to speak with a doctor right away.

Cialis can cause side effects, such as:

    How long does it take for Cialis to work?

    The onset of action of Cialis may vary depending on the individual and the medication. The effects can last for up to 5 hours, allowing for spontaneous sexual activity. However, it is important to note that the effects of Cialis may last for up to 36 hours after ingestion, making it a common issue for most men. This period can vary depending on factors such as food intake, metabolism, and overall health. The effects of Cialis can last for up to 24 hours, and it is important to complete the full course of medication even if you start to feel the effects.

    If you experience any of the following symptoms, it is important to contact your doctor immediately:

    • Vision changes
    • Blurred vision
    • Trouble hearing or seeing things that are not there

    What are the side effects of Cialis?

    Cialis can cause side effects such as:

    • Headache

    If you experience any of the following side effects, it is important to contact your doctor immediately:

        What are the precautions?

        Cialis should not be taken by individuals who are hypersensitive or allergic to tadalafil or other similar medications.

        Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

        Common side effects reported from Cialis use include:

        • Headache
        • Indigestion
        • Heartburn
        • Upset stomach
        • Gas
        • Nausea
        • Flushing

        More severe side effects include:

        • Painful erections or erections that last longer than 4 hours
        • Sudden loss of vision
        • Sudden loss of hearing
        • Ringing in the ears
        • Chest pain
        • Shortness of breath
        • Painful urination
        • Increased urination frequency
        • Fainting
        • Dizziness
        • Skin rash
        • Hives
        • Facial swelling

        If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

        As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

        Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

        In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

        How long after treatment does Cialis last?

        No, Cialis doesn’totype works for time. Its dose-dependent effect remains after treatment is finished.

        What is the active ingredient in Cialis?

        The active ingredient in Cialis is tadalafil.

        What is the dosage?

        The recommended starting dose is half a tablet of Cialis taken once daily.

        What is the duration of treatment?

        Cialis will not be stopped if there is no improvement in your symptoms for more than four consecutive days.

        How do I inform?

        Let your health care provider know if you are currently taking any form of medication. They should advise you on the appropriate regimen for you.

        What is the sig?

        This medication is typically taken when you are sexually active. If you take Cialis while you are sexually active, your blood pressure will likely be slightly higher than usual. However, this may not be the case when you start treatment. As a result, you should feel more relaxed when you are sexually aroused.

        Some health care providers recommend a starting dose of 10mg Cialis once daily.

        The recommended starting dose is 10mg once daily.

        The recommended starting dose is 20mg once daily.

        How is Cialis taken?

        Cialis is taken orally, with or without food.

        The recommended starting dose is 10mg once daily, then 20mg once daily.

        The recommended starting dose is 20mg once daily, then 20mg once daily.

        What should I avoid while taking Cialis?

        Avoid engaging in sexual activity until your treatment is over.

        What should I tell my health care provider before I begin treatment?

        Tell your health care provider if you have any health conditions or are pregnant or plan to become pregnant. If you have any changes in your health condition, such as a prolonged erection or flushing, they should immediately stop treatment and contact your doctor.

        Erectile Dysfunction

        Erection problems (impotence) are very common, particularly in men over 40.

        Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.

        If it happens more often, it may be caused by physical or emotional problems.

        Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.

        Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety

        Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week

      • Side Effects

        Possible side effects

        Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

        If you experience any of the following side effects stop using the medicine and seek medical help immediately:

        allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:

        Common (seen in 1 to 10 in every 100 patients)

        headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)

        dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)

        fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.

        Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

      • Room temperature (24 to 30 degrees Celsius).

        All medicines can cause your normal drug action potential to diminish. This is particularly true for CIALIS.

        You should not use CIALIS if you have a known allergy to CIALIS or any of the ingredients in CIALIS.

        guyen /leslie

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